EXTRACTS FROM EXCHANGES. 
521 
forms in a draught, are comparatively ineffectual when com¬ 
pared with the drug administered through the trachea. 
A minor consideration is the corrosive action of the iodine 
upon one’s syringe. If my belief in the future is warranted, a 
non-corrosive syringe (possibly of vulcanite) will become a 
desideratum.— Vet. Record. 
COCAINE—ITS THERAPEUTICAL USES AND TOXICOLOGICAL 
EFFECTS. 
In the March issue of th z Journal of Comparative Pathology 
and Therapeutics Mr. F. Hobwav published a long and excel¬ 
lent article on the above subject, where he reports a large 
number of experiments which he has made in studying the 
numerous and various effects of cocaine in the horse, dog and 
cat. 
From the ninety-nine cases upon which he has experi¬ 
mented, he arrives at the following conclusions: 
1. Cocaine hydrochlorate is a drug whose therapeutic 
value in certain cases is unquestionable, but its use on all ani¬ 
mals is attended with danger unless proper care is taken to 
estimate the amount which can be used with safety. 
2. It is a drug which can readily be absorbed from subcu¬ 
taneous, serous or mucous tissues, and it is of value as a local 
anassthetic in surgery and in certain affections of the stomach. 
In surgery there is danger of interference with the opera¬ 
tion if too large a dose (although not toxic), be given, on ac¬ 
count of the violent involuntary clonic spasms of the volun¬ 
tary muscles. 
3. The doses which can be used with effect and at the 
same time with safety are : 
For the horse, subcutaneously, not more than ten or eleven 
grains. 
For the dog, subcutaneously, not more than two grains of 
cocaine hydrochlor., if about the size of a fox terrier, or four 
grains, if of the size of a collie. By the mouth, the toxic dose 
is much larger, but the purpose is effected by doses varying 
from one to four grains. 
