CONTRIBUTION TO THE STUDY OF SWINE PLAGUE, ETC. 565 
It remains for me to mention two cases where the sub¬ 
cutaneous injection of virus in the abdomen, on rabbits on 
the road to vaccination against swine plague , had occasioned 
death by the extension of the local abscess to under the skin 
of the abdomen, of the thorax and of the back. 
The brain, examined on several occasions, presented no 
lesion. 
In the cases of acute intoxication the symptom, diarrhoea, 
was present as after the injection of virulent culture; often, 
especially after injection of toxine of hog cholera , there was 
also tumefaction of the spleen. In chronic cases, by oppo¬ 
sition, one would notice loss of flesh, cachexia, marked dim¬ 
inution in the size of the stomach, and especially an atrophy 
of the spleen, often excessive. Of course, in both cases cul¬ 
tures were sterile. 
To resume, the anatomical lesions are analogous in the 
acute cases of hog cholera and of swine plague; the more in¬ 
tense diarrhoea and the more marked increase in the size of 
the spleen are only quantitive differences, perhaps connected 
with the little longer durations of the disease; they are not 
sufficient to differentiate hog cholera . 
The local reaction after subcutaneous injection does not 
either allow the distinction of the two diseases. At first this 
reaction is marked in swine plague , but we have seen also that 
in hog cholerci it diminishes as the virulency increases. Be¬ 
sides, in the cases of partial and incomplete vaccination 
against swine plague , the tumefaction was much larger than 
with the injection of the virus of hog cholera to a fresh rabbit. 
From these facts I believe I am authorized to conclude: 
First .—The anatomical lesions and the morbid symptoms 
do not allow the differentiation between the two diseases. 
Second .—It is impossible, as done by several authors, to 
distinguish the two diseases by the lesser or greater exten¬ 
sion of the purulent formations, so long as we have demon¬ 
strated that, for one and the same disease, one can observe 
all degrees of local reaction, from the simple circumscribed 
hyperemia to the generalized abscesses with purulent pleu¬ 
risy, purulent peritonitis and purulent collections in the 
lungs. 
