566 
W. SILBERSCHMIDT. 
Third .—In the numerous post mortems that I made upon 
hundreds of rabbits I have failed to observe a pulmonary 
localization of the lesions in swine plague, or a rather intesti¬ 
nal localization in hog cholera. 
INFECTIOUS PNEUMO-ENTERITIS OF SWINE. 
Mr. Metchnikoff has kindly given me a number of tubes 
of blood from rabbits dead after the injection of the bacillus 
of infectious pneumo-enteritis of swine. This blood, kept 
for more than a year, contained only a small number of liv¬ 
ing microbes. I obtained a pure culture after an injection of 
2.5 c.c. of this blood to a rabbit, and it is starting from this 
culture that I made my experiments. 
To the morphological point of view, the microbe that I 
have studied presents a great resemblance to my bacillus of 
szvine plague: small dimensions, transparent colonies upon 
gelosis, and no formation of gases in glucosed bouillon in the 
presence of carbonate of lime. The virulency was weak, 
less constant, and was nearest that of hog cholera at first. 
With subcutaneous injection it required 0.2 to 0.3 c.c. of cul¬ 
ture or of virulent blood to kill a rabbit with certainty. In 
one case the rabbit resisted an injection of 0.1 cc., and another 
died after only twenty-two days of cachexia. According to 
the dose death occurred in eighteen hours, or between two and 
three days. 
The intravenous injection of x / 2 cc. and more killed be¬ 
tween twelve to twenty-four hours in average. The local re¬ 
action, which, as we have seen, acts in inverse proportion to 
the virulency, was always considerable, and was even greater 
than that produced by the subcutaneous injection of hog 
cholera ; the injected ear was always the seat of a quite large 
oedema, with formation of abscess. At the post mortem the 
lesions were analagous to the two other diseases. 
The guinea-pig dies in from twelve to twenty-four hours 
after a subcutaneous injection of to 1 cc. of virulent blood ; 
a mouse, which had received cc. of the same blood, died 
the eighth day. 
The toxicity of the sterilized cultures, and of the blood, 
