572 
EXPERIMENTAL PATHOLOGY. 
shoulder. Ten times he obtained a local swelling, more or 
less developed; six times general symptoms; five times the ap¬ 
pearance of small vesicles on the teats; he has found the diph¬ 
theria bacillus constantly in the liquid of the vesicles and 
twice in the milk .—Revue des Sc. Med. 
ON THE USE OF MALLEINE IN MAN AND ANIMALS TO THE POINT 
OF VIEW OF DIAGNOSIS AND OF THE THERAPEUTY. 
By A . Bonome. 
The animal which seems the least sensitive to malleine and 
the most proper to establish its diagnostic value is the rabbit. 
The cat comes next, the guinea-pig and the dog resist much 
more. 
The injections of malleine to horses cannot be considered 
as positive means of diagnosis of glanders; the experiments 
of Bonome, made on 32 horses, agree with the conclusions of 
the French commission appointed by the Secretary of War. 
Out of the 30 horses to which an injection of 1 to i|- c.c. of 
malleine had been made, 24 showed a more or less severe feb- 
rile reaction, 6 did not react. Of the 24, 19 were killed, and, 
with one exception, all had the manifest lesions of glanders. 
Of the other five which were not destroyed, one only, by in¬ 
oculations to guinea-pigs and dog and by cultures, gave 
proofs of glanders. Thus the febrile reaction that is obtained 
through malleine is not a positive criterion of the existence 
of glanders in the horse. 
The author has had occasion to treat, with malleine, a case 
of human glanders. This observation, unique at this day, 
brings him to the following conclusions:— 
1st. Malleine obtained by cultures gives to the man af¬ 
fected with chronic glanders a reaction far less violent than 
in the horse. Two or three drops are sufficient, instead of 
1 c.c., as required by the horse. The intensity of the reaction 
is proportionate to the dose, but goes on decreasing as the 
injections are repeated. 
2d. Each injection gives rise to an cedematous and pain- 
ful swelling, which rapidly disappears. 
3d. During the days following the injection, the temper- 
