CONTRIBUTION TO THE STUDY OF SWINE PLAGUE,,ETC. 699 
No. 331.—Injection of 3 cc. of the serum of rabbit No. 107. Test after 24 
hours ; immediately after, new injection of ^ cc. of serum; these injections of 
serum are repeated the following days : the next day, large oedema of the ear, two 
injections of 1 cc. each ; the two following days, one injection of 1 cc. ; the fourth 
day the oedema increasing. I make two injections of i }4 cc. each ; the fifth day I 
inject 1.25 cc., the rabbit dies during the night, or five and a half days after the test; 
the witness died in less than 16 hours. Then longer life of five days. At post 
mortem, alongside the enormous oedema of the left ear, there is purulent pleurisy, 
unilateral, on the left side with pericarditis. 
No. 333.—4-VI, ik-750, at 55 minutes after 3 o’clock, injection of virulent 
culture of swine plague killing witness in 16 hours. At quarter past 7, 3 hours and 
one-half later, the rabbit receives 4.5 cc. of serum of rabbit No. 107. The next day 
the temperature is 39 0 4 in the morning, 41 0 1 at 4 o’clock p.m. ; two injections of 2 and 
of 1 cc. of serum. 6-VI, ik-665 ; ear oedematous ; 49 0 at 10 o’clock A. M., injection 
of i.cc. of serum; at 4 o’clock P. M., 42 0 . Injection of 2 l g cc. 7-VI, 9 o’clock, 39 0 9, 
ik-550. Injection of 1%, cc. of serum, 7:30 P. M., 41 0 5; injection of ]/ 2 cc. of 
serum. 8-VI, ik-550 ; 9 o’clock 39° 7. Injection of 1.75 cc. of serum and second 
injection of the same dose at 5 o’clock P. M. The rabbit dies during the night—he 
resisted four days longer than the witness. 
At the post mortem, lesions are identical with those of No. 331. Ear much 
oedematous and ulcerated, purulent pleurisy with pericarditis, part of the lung hepa- 
tized. Microbes in the blood and in the pus. Pure cultures. 
No, 335.—8-VI, ik-665 ; at 9 P. m., injection of of virulent culture of swine 
plague , rectal temperature was 39° before the inoculation. The witness dies during 
the night. 
At quarter to 3, 3^ hours after the testing injection, the thermometer indicates 
40° 2 ; injection of 7.5 cc. of the serum of rabbit No. 198. 9-VI, 40° ; injection of 
2 cc. at 10 A. M. 10-IV, 41° 4 at 10 A. m., injection of 2.5 cc. of serum. 11-VI, 
ik-770. The oedema increases, 40° 3. Injection of 3 cc. of serum. The 12-Vy 
the ear being very much tumefied, I make some small scarifications, washing with 
sublimate solution and painting with tincture of iodine, I inject besides 3 cc. of serum 
in the morning and 2 cc. in the evening. 13-VI, 40 0 3. Weight ik-625. Injec¬ 
tion of 2.75 cc. in the morning, and 2 cc. in the evening. The 14-VI in the morn¬ 
ing, the rabbit is lying down on its side, and notwithstanding a last injection of 
3.5 cc, of serum, dies towards ir o’clock a. m., five days and a half longer life. 
Autopsy —Abscesses disseminated through the lungs with circumscribed heaptiz- 
ation in both cases. The blood gives a pure culture, but not very abundant. 
I succeeded only in two cases to protect rabbits against 
swine plague with preventive in jections of the serum of vac¬ 
cinated rabbits; in both cases a second test has killed the ani¬ 
mal, which proves that immunity thus conferred does not last. 
In my numerous experiments, the rabbits have presented, 
after preventive injection of 2 cc. and more of the serum of 
vaccinated animals, a marked and constant extent of life com¬ 
pared to the witnesses, which was never observed in fresh 
