REPORTS OF CASES. 
711 
until the next day, when he was brought to the office, and a 
diagnosis of incipient tetanus was made, and it was advised 
to have the animal unhitched and removed to his stall. 
Nerve sedatives and anti-spasmodics were given, but the 
animal grew steadily worse, and on November 3d it was a 
well marked case of tetanus. The muscles of the trunk and 
limbs were now stiff, but trismus had not as yet occurred, and 
with assistance the animal was able to rise when down. 
Having read an article by Paul Gibier, M.D., Director of 
the New York Pasteur Institute, on the treatment of this 
disease in man by the use of antitoxin, and to whom I am 
indebted for some of the above statements, I suggested to the 
owner that we send to the institute for a sufficient quantity 
of antitoxin to give it a fair trial, if it did not cost too much,, 
and he consented. Before the arrival of the antitoxin, on the 
morning of November 7th, the horse was found lying in the 
stall unable to rise. Slings were put under him and on being- 
raised to his feet was unable to stand. The entire muscular 
system was stiff and the jaws locked. Respiration was rapid 
and conducted with much difficulty. The slightest disturbance 
would bring on spasms, and it looked doubtful if the horse 
would live any length of time. 
On November 9th, a supply of antitoxin sufficient for 
three injections was received from the institute, and at 4:15 
P. M., assisted by my father, the first injection was made. 
The hair being first shaved from portions of the neck, the 
parts were washed with a solution of carbolic acid, and the 
antitoxin in solution was injected hypodermically. Im¬ 
mediately before the injection the pulse was 44, temperature, 
ioof Q F. and respiration 72. The wound was washed with 
iodine, 1 ; potassium iodide, 2; and water, 100 parts. When 
the second injection was given next morning, the respirations 
had dropped to 55, pulse 40, and the temperature had risen to 
ioi|°F. Improvement in the condition of the muscles of the 
body and limbs were general, while the muscles of the jaws 
were decidedly improved. The neck being moved from side 
to side, instead of being held in a straight line as previously. 
On November nth the third injection was made and a 
