94 
W. L. ZUILL. 
case of this kind in my practice in May, ’93, the brief history o 
which is as follows: Among the horses purchased for a brewing 
firm was a thoroughbred shire mare; three or four days after the 
purchase the leg of this animal was clipped, and a day or two 
after she developed typhoid fever, it being prevalent in the 
stable at the time. The disease seemed to expend its entire 
force upon the extremities, all four of which swelled to enormous 
proportions, were hot and painful, diffused suppuration of the 
cellular connective tissue developed, and the animal died of 
pyasmic infection in about ten clays after. It would appear that 
the removal of a heavy coat of hair, early in the Spring, and 
just at the onset of the disease, caused such irritation of the 
parts as to cause a localization or concentration of the disease 
at this point. 
In summing up the prognosis, therefore, it will be seen that 
there is abundant reason for considering this disease a very 
serious one; even much more serious than certain other con¬ 
tagious diseases which are under legal control, such as glanders 
and farcy. My experience with this disease leads me to think 
that a death rate of about 6 or 8 per cent, is to be expected, 
although a few years ago it was placed as high as 20 per cent. 
Anatomical Changes. —There is such a remarkable varia¬ 
tion in the anatomical changes that they have frequently been 
confounded one with the other, and which for a long time 
tended to obscure the true character of the disease, and pre¬ 
vented the distinct recognition of the primary changes from 
those which were secondary. I shall first endeavor to point 
out those changes which are essential, and later will consider 
those which are secondary. We will first notice that the blood 
has undergone special and peculiar changes, which will be 
noticed before any other change or localization can be recog¬ 
nized. The disease has been described as an enteritis, or a 
pneumonia, due to these changes in the blood, and it was for 
this reason that the term typhohaemia was applied to it. In 
order to determine the nature of the lesions, it was necessary to 
keep a careful record of the conditions found in post-mortem 
