i 
66o E. ROUX, L. MARTIN AND A. CHAILLOU. 
striking ? Of course not, as long as your prosperous institution 
has commenced with a good atteudane of students from all pcirts 
of the continent , the West Indian Islands , and even from Great 
Britain ; and in that case, why say “ Students can still enter ? 
Is it the application of the railroad horse-car company’s old 
motto, “Move forward, please; more room inside, with the 
pulling of the bell for railroading through. 
ORIGINAL ARTICLES. 
CONTRIBUTION TO THE STUDY OF SERUM-THERAPY IN 
DIPHTHERIA * 
By E. Roux, M. D., Chief of Laboratory of the Pasteur Institute, and Drs. L. 
Martin and A. Chaillou, Internes of the Hospitals of Paris. 
Serum-therapy is one of the most important questions of the 
day since the researches of Behring and Kitasato. Tetanic anti- 
toxine was studied first, as being the easiest to obtain and be¬ 
cause its preventive action is manifested with a marvellous 
potency. In practice it has not justified all our hopes, and 
everyone recognizes the fact that while always useful in tetanus, 
it is not an absolutely certain remedy. The reason for this is 
that we are only able to recognize tetanus when contractures 
occur, i. e., when general poisoning has already taken. place. 
This, however, is no longer a fact in diphtheria, for, while it is 
also a toxic malady, the poisoning follows the. presence of an¬ 
gina or laryngitis, and we are warned, by the presence of the 
false membranes, before the poisoning has become declared. 
Since 1891 we have pursued a series of experiments in the 
treatment of diphtheria by the antitoxic serum, at first upon 
animals, and later on children. Before publishing anything on 
this subject, we determined to obtain a sufficient number of 
* Read at the Congress of Hygiene at Buda-Pesth. Extract from the A'. Y. 
Therapeutic Review. 
