NOTES UPON MALLEINE. 
_______ 671 
children. The anatomo-pathological lesions are the same. 
In both cases there is broncho-pnemonia with abundant bron- 
chial secretion. 
In these cases of associated diphtheria the serum but rarely 
cures. This is not because there is a formation of larger 
amounts of diphtheritic toxines, or because the antitoxine action 
is hindered, but because the cells that are stricken by the 
poison of the streptococci no longer feel the stimulation of the 
antitoxine. In a number of other experiments the animals 
reated 12 hours after the inoculation invariably died, notwith¬ 
standing repeated injections of the serum. We frequently 
saved rabbits, treated seven or eight hours after, by repeated in¬ 
jections of serum. It is here important to repeat the injections 
m or der to be assured of a definite cure. 
Would we obtain better results in these associated cases by 
the simultaneous injection of anti-diphtheritic serum and the 
serum of rabbits immunized against erysipelas ? Dr. Marchoux 
o the Pasteur Institute, has supplied us with a serum of this 
sort which, however, has as yet failed to give us good results, 
though a rabbit inoculated with it outlived for several days a 
control rabbit. Perhaps this serum was not sufficiently effica¬ 
cious against the sort of streptococcus that was employed. 
NOTES UPON MALLEINE. 
By Prof. E. Nocard, of Alfort. 
hese are the resume of many experiments made with my 
friend, Dr. Emile Roux, of the Pasteur Institute, which have 
een made upon over nine thousand horses with the malleine 
prepared at the Institute which above all qualities has the ad¬ 
vantage of being always the same and identical to itself in its 
action. 
_ TllIS q uallt y is due to its mode of preparation. We use, as 
unique seed or element (semence) a glanderous bacillus whose 
