notes upon malleine. 
___ 673 
malleine or two cubic centimeters in mTl^T^TfT^ 
8th) & ives rise to a characteristic reaction. 
: fl In a fSW h ° Urs ’ at the seat of inspection, there appears an 
Se m rZs tUmefaCti ° n r Wa ™’ tenS6 ’ V6ry ^ 
g at times enormous, from the circumference of which start 
lymphatic sinuous tracts or cords, also warm and painful, ex- 
^ g 0 p tlC cl H cl t ll 0 * * 1 ' . 1 ^ malleine is 
P nd . the ,n J ectlo n made aseptically, this tumour never 
suppurates, it increases for 24_36 hours n nr i • c 
a j.1 4 nours and remains for several 
by de8re " “ d «»'y 
: r'T'T ; he '~ k »”»<■», th« h* *, ,„ d ; e 
ank is studied up, the respirations accelerated, the appetite is 
orTurlT m T ^ ^ freqUent trembIi "g s of the olecranon 
ci ural muscles, or even the trunk is taken with strong con¬ 
vulsive contractions ; if the animal is made to move its miser- 
e appearance, stupor and deep prostration are surprising, the 
ost powerful, active or even dangerous is entirely changed he 
ts wea , and indifferent to all surroundings. These general 
phenomena constitute what in France we call the organic re- 
ion, they are not always as severe, and though they may 
aiy in severity they are never entirely wanted. 
By opposition the thermic reaction is never absent. In a few 
hours he central temperature of the glanderous horse rise! 
P a Ua y 10m ' J5, 2 ° 2 °5 and even more above the normal. I 
lave seen one case in which the hyperthermic brought on by 
the injection of malleine rose, after the 10th hour, 4 centigrade 
degrees (from 3 8°2 to 4 2°2). g 6 
8th T'" e ‘ e '' ati011 ° f the temperature already visible from the 
<- th hour after the injections, lasts a long time; reaching its 
ax,mum between the 10th and 12th hour, at times even after 
the 15th and more rarely towards the x 8th hour. 
in of f T imp , 0rtant t0 notice is that the phenomena following 
b nderous horses the injection of malleine lasts a long time; 
