NOTES UPON MALLEINE. 
675 
tions in the temperature of the patients. When cases of this 
kind are suspected, one must be certain that the hyperthermia 
following the injection of malleine is lasting, and that the 
organic reaction is also present. 
5. P is seldom that a case of glanders remains isolated in a 
stable containing a certain number of horses ; the rule is that 
other animals become affected in their turn. But, before pre¬ 
senting evident and visible signs of the disease which indicate 
t e need of sanitary precautions for them, they may have already 
spread the germs of the disease and contaminated other animals. 
Injections of malleine allow to ascertain that, in such a case, 
the number of animals really contaminated is always greater 
than one would suppose if depending only on the simple clinical 
examination. 
If the animals thus condemed by the malleine are, all or only 
some of them destroyed, the examination of their lungs will always 
reveal lesions of glanders, at times in great number, or again 
united and represented only by small rounded nodules, firm to 
the touch, of the size of a millet seed, yellowish or greyish in 
color, semi-transparent, homogemous in their entire thickness 
without fibrous wall on their periphery, without caseous soften-’ 
mg 111 their center; the glanderous origin of these translucid 
tubereles is no longer a doubt in our days. 
But if, instead of destroying horses condemned by malleine, 
the> me kept isolated, away from any chance of new contamin¬ 
ation, only a small number of them will sooner or later exhibit 
the clinical signs of glanders; while the others will remain with 
all the appearance of health, will be returned to their work and 
none will become glanderous. 
If, while they are kept isolated, these horses are periodically 
submitted to the test of glanders, the number of those that will 
react will gradually and at each test diminish in such a way 
that, after several months, most of the animals which had been 
condemned by the first inspection may be considered as healthy; 
they behave like those which had not reacted at the first test, 
they never present any symptoms of glanders, neither do they 
