SOME EXPERIMENTAL RESEARCHES ON THE 
USE OF MALLEINE. 
7 09 
tutional changes ; in other words, no local or general reac 
tion. 
(f‘) upon diseased individuals , but not glanderous or 
suspicious. I have injected malleine into animals affected with 
diseases entirely different from that for which it is indicated, and 
with what result ? In almost all, the same upon which Prof 
Nocard has so well called the attention of the veterinary world, 
viz., a negative result, without any reaction. It is thus that in 
a case of suppuration of the sinuses, with necrosis of the palate 
(obs. 3), 111 a case of chronic suppurative synovitis of the hock 
(obs. 6) ; one of maxillary adenitis with lymphangitis of the 
face (obs. 12), a cold abscess of the shoulder with suppurative 
synovitis (obs. 18), and in a case of extensive suppurative 
lymphangitis of the left hind leg (obs. 32), in these five cases 
there has not been any general reaction nor any rise in the 
temperature. If in Observation 32 there has been some general 
reaction, it has been so irregular and so analogous to that 
existing during the whole sickness, that it can scarcely be con¬ 
sidered as pathognomonic and belonging to the effect of 
malleine. 
There are, however, two cases which are of some impor¬ 
tance, I believe, because they may have a tendency to prove 
tnat, after all, malleine might react in other diseases besides 
glanders. 
Obseivation 8 was obtained upon an animal which was to be 
used lor dissections, and upon which there was no indication of 
glanders. He received malleine,—he reacted,—and at the 
post-mortem the only lesions found was a small pulmonary 
abscess of the size of a large apple upon the anterior lobe of 
each lung; of glanders, nothing. 
Observation 35, made upon a horse condemned on account 
of a suppurative pneumonia of fifteen days’ existence, in showing 
an elevation of temperature of 2 4-5 0 F., joints the preceeding 
as an exception to the rule. 
From these two observations, and the fact that malleine is 
also so demonstrative in cases of pulmonary glanders, is it 
