;■ -v-' V 
REPORTS OF CASES. 
857 
REPORTS OF GASES. 
MALLE1NE IN GLANDERS. 
By W. SiEGMUND, D.V.S., House Surgeon, American Veterinary Hospital. 
Although a great many reports as to the diagnostic value of 
malleine have been published, I may be allowed to report the 
following case : 
A brown gelding, 10 years of age, was brought to the hos¬ 
pital for scientific purposes. The animal, to all external pur¬ 
poses, although not sound in limbs, exhibited all signs of health ; 
the eyes bright, pulse, respiration and temperature normal. 
Visible mucous membranes of the normal, rosy red, smooth, 
glistening appearance, Lymphatic glands of the inter-maxillary 
space normal. Appetite and thirst normal, defecation and mic¬ 
turition normal. 
As is customary, animals secured for the special purpose of 
obtaining a therapeutic agent, are subjected to the test of mal¬ 
leine, to insure against the presence of latent glanders. The 
animal in question was injected with malleine at 10 o’clock one 
evening, the temperature being normal, 99 3-5 0 F. 
Twelve hours after, the following morning at 8 A. M., the 
temperature registered 104 1-5 0 F., with an accelerated pulse, 
irritability, and a swelling several inches in diameter at the point 
of inoculation. The temperature varied from 103° to 104 2-5 0 
during the day, returning to normal the following day. The 
swelling subsided, the membranes remaining clear. 
Being a suspicious case, the animal was again subjected to 
the test at 10 o’clock in the evening, the temperature and pulse 
being normal. 
The next morning at 8 o’clock the animal presented a pitiful 
appearance. Anxious expression, dilated pupils, nostrils dilated, 
mouth hot and dry, large swelling at the seat of inoculation, back 
arched, flank tucked up ; difficult and painful defecation of hard 
dry faeces, driveling of viscid, highly colored urine, slight swell- 
