274 
G. A. JOHNSON. 
tone, loss of appetite, accompanied by a startled staring appear¬ 
ance, soon followed by a mild frenzied state, in which an affected 
animal, that formerly had been perfectly gentle, would be great¬ 
ly alarmed at the approach of a person and would wildly run 
away, but as the disease progressed, which was rapidly, this 
timidity was lost and the animal would become aggressive and 
chase other animals of the drove and later it would attack any 
animal or person, and especially a dog or hog, and during the 
most aggressive stage would attack moving objects, from the 
size of a mouse up. At this stage of the disease paralysis began 
to supervene and then there would be alternate periods of frenzy 
and partial coma. The frenzied periods growing shorter in dur¬ 
ation and less in severity, while the periods of coma correspond¬ 
ingly increased in duration and profoundness until complete 
paralysis supervened. During the early stages of the disease 
the bowels move quite freely but during the latter stage there is 
usually a slight constipation. The faeces are nearly if not al¬ 
ways of a dark color. During the early stages of the disease 
small quantities of highly colored urine are very frequently 
passed. 
The pupils of the eyes are usually fully dilated. Prognosis: 
death; so far as I have been able to learn the disease always 
terminates in death. 
Necropsy, revealed a normal condition of all the inteinal 
viscera, except that in a few cases the kidneys were slightly 
congested and in about 5% of the cases the abomasum was im¬ 
pacted, but in no case was there any marked engorgement. 
But upon opening the cranial cavity and spinal column, we found 
marked lesions of inflammation, especially in the brain when all 
the membranes, especially the pia mater, showed marked in¬ 
flamed areas and the cavities contained more or less inflammatory 
exudates, while those of the spinal column contained more or 
less fluid and the membranes were more or less inflamed, 
especially in the lumbar region. That portion ol the pia mater 
covering the anterior-inferior portion of the cerebrum besides 
showing the most marked congestion, was of a dark color. I 
