REPORTS OF CASES. 
2f)4 
In cutting the skin a straw-colored serosity was noticed 
to escape, but very little blood. The subcutaneous areolar 
tissue was infiltrated by material, varying one-half to one and 
a half inches in thickness, gritty under the knife, interrupted 
here and there by a small ulcer. After passing through this 
tissue a cavity was found measuring 2 x 23^ inches in diameter, 
following the course of the femoral arteries. This cavity con¬ 
tained pus and blood. The surrounding muscular tissue was 
anaemic; the intercellular tissue was of yellow color, prominent 
and modelling the muscular tissue. The deep inguinal glands 
and popliteal glands could not be found. 
The subsacral lymphatic glands, reservoir of pecquer, spleen 
and thoracic duct were normal. The lymphatic vessels on the 
mesentary stood out prominently, appearing like the arteries do 
when injected with plaster. 
THE TOXIC EFFECTS OF COCAINE AA. LOCAL ANASTHETIC. 
By W. W. Yard, D.V.S., House Surgeon, New York City. 
A large water spaniel bitch, ten years old, weighing about 
seventy-five pounds was brought to the hospital April 24th, for 
the removal of a large Sarcoma of the mammae. Patient other¬ 
wise seemed to be in perfect health. All precautions being 
taken as to the age of the animal, a 4% solution of freshly pre¬ 
pared cocaine was hypodermically injected at six different 
points, patient receiving about 40 minims or 1 3-5 grains of the 
drug itself. After ten minutes had elapsed the operation was 
commenced and the tumor removed, accompanied with con¬ 
siderable haemorrhage. Nothing abnormal being noticed but a 
slight dilatation of the pupil. The parts were antiseptically 
washed and dressed, and patient placed on her feet, but immed¬ 
iately fell to the floor, as if exhausted. When urged to move 
she staggered to her feet and moved round the room tossing 
head first to one side then the other and crossing one fore leg 
over the other. This continued for about ten minutes, and ani¬ 
mal fell to the floor in tetanic twitching of muscles and champ- 
