GLYCOSURIA produced experimentally in animals by physical excitations. 331 
GLYCOSURIA PRODUCED EXPERIMENTALLY IN ANIMALS 
BY PHYSICAL EXCITATIONS* 
By Paul Gibier, M.D., Director of the New York Pasteur Institute. 
Physiologists have produced hyperglycaemia, glycosuria, and 
even fatal diabetes mellitus, by various processes, such as irri¬ 
tation of the floor of the fourth ventricle (Cl. Bernard), of differ¬ 
ent portions of the brain, spinal cord, spinal and sympathetic 
nerves, (Schiff, Pavy, Aladoff and Cyon, Eckhard, Klebs and 
Munck, Filehne, Vulpian, &c.), intoxication or poisoning by 
means of substances too numerous to enumerate, but foremost 
among which phloridizine may be mentioned (Von Mering), 
traumatism of the skull, and excision of the pancreas (Von 
Mering and Minkowski, Lepine and Hedon, A. Chauveau and 
Kauffman). 
Glycosuria may also appear spontaneously in animals and 
cause death, but in such cases the etiology of the disease appears 
to be, if possible, still more obscure than it is in man. In the 
latter, it is admitted that glycosuria may appear under the influ¬ 
ence of numerous causes; as in lesions of the nervous system, 
the liver and the pancreas; traumatism, intoxications, or poison¬ 
ing, and disorder of nutrition. Without discussing the opinions 
of theorists on diabetes, who have proposed many classifica¬ 
tions of this disease, one that it is generally admitted that 
glucose may be directed in the urine of man after certain men¬ 
tal disturbances, as, for instance, on the eve of a dreaded surgi¬ 
cal operation, after great worry, the loss of a fortune by ruined 
financiers, whose hygienic state is generally favorable to the 
disease. In short, the influence of any violent moral commotion, 
of variable duration, predisposes the victims to this affection, and. 
without appreciable prodromata, glycosuria takes root and often 
completes the destruction inaugurated by anxiety. 
If analogous instances have been observed in animals, I have 
been unable to find any reports in the literature of the subject. 
*Read before the Biological Section of the N. Y. Academy of Sciences, April 9, 1894. 
