640 
EXTRACTS FROM FOREIGN JOURNALS. 
EXTRACTS FROM FOREIGN JOURNALS. 
PROGNOSIS AND THERAPEUTIC VALUE OF THE PRODUCTS OF THE 
BACILLUS OF GLANDERS. 
By M. Bonome, Padua. 
The author has made numerous experiments upon the action 
of malleine in animals and even in man. 
All animals have not an even sensibility to the pioducts of 
the bacillus. The donkey and the cat lose flesh rapidly and 
suffer with conjunctival and nasal catarrh. At times they have 
pustulous eruptions and a lowering of the temperature when 
very small doses of malleine are given every twenty-four or 
forty-eight hours. Rabbits react very easily; they die very 
readily after subcutaneous injections of a few drops of malleine. 
Dogs and Guinea-pigs, affected with experimental glanders, react 
by rapid emaciation and extension of their glanderous lesions. 
As a means of diagnosis the author has used it in thirty-two 
suspicious cases ; twenty-four reacted ; eighteen of these were 
destroyed, and the diagnosis confirmed in seventeen. The 
eighteenth had none. The other six animals, which weie not 
destroyed, did not show any other indication of glanders, and 
the inoculation of their secretions gave also negative results 
Experimented on man malleine at the dose 1-15 to 1-20 of 
a cubic centimeter, has given a febrile reaction, with increased 
circulation, polyuria, headache and swelling of the mucous 
membrane affected. The reaction lasted from six to thirty hours. 
Similar doses, given after a rest of two or three days, produced a 
great improvement in the manifestation of the patient. 
In spontaneous glanders Mr. Bonome has obtained good re¬ 
sults. Fourteen injections of malleine, made in forty-five days, 
were followed by the disparition of the symptoms, and have re¬ 
mained free of them for over a year. Dogs affected with 
glanders were also cured by injections of malleine. Glanderous 
Guinea-pigs were not cured with the malleine, except a few which 
were treated with the serum ot beef blood, which had been for 
two weeks in contact with the bacillus of glanders .—Inter . Cong, 
of Rome. 
