VETERINARIUS. 
74 
It now became a matter of great importance to demonstrate 
the presence of the same bacilli in the organs of other animals 
that had been inoculated with material from glandered horses and 
acquired the disease beyond all doubts. Rabbits inoculated with 
fresh material in the ear and abdomen did not present the symp¬ 
toms of general infection, an ulcerative process only developing 
at the locus inoculationis. The eventual demonstration of the 
bacilli in the peripheries of ulcerations, standing in direct relation 
with the external world, could not be of a pathogenic value, as an 
objection could be raised that they had gained access to the tis¬ 
sues from without. In guinea-pigs the conditions were quite dif¬ 
ferent, as in them not only were local processes developed, but a 
thoroughly characteristic infection of the internal organs followed 
the inoculation. Illustrated by the following examples: 
First case. A portion of an old glanderous nodule from ahorse 
was introduced under the skin of a guinea-pig, and in fifty days 
the animal died. Autopsy: Long, fluctuating tumors on the left 
axilla; spleen studded with numerous greyish-yellow miliary nod- 
uli, as well as the liver, though the neoplasms in the latter were much 
smaller than in the spleen, and of a grey color. The left supra¬ 
renal capsule contained a yellow node, as did also the epididymis 
of the same side. One of the retroperitoneal glands was hyper¬ 
trophied, as large as a cherry, and filled with a delicate, greenish- 
white puriform material. The nasal cavities were filled with a 
purulent mass, the mucosa being ulcerated in many places. Simi¬ 
lar results do not follow the artificial inoculation of guinea-pigs 
with other infectious material or any natural disease to which 
they are subject, therefore the above disease cannot be considered 
as any other than glanders. In covering glass preparations from 
the nodules of this guinea-pig, as well as sections from the tissues 
treated with methyl-blue, the same fine bacilli were recognized as 
demonstrated by the cultivating methods. 
Second case. A guinea-pig was inoculated in the posterior ab¬ 
dominal region with fine particles of a glanderous neoplasm from 
the lung of a diseased horse. The animal died in twenty-seven 
days. Autopsy: Ematiated rough coat; axillary and inguinal 
glands of the right side swollen and fluctuating; on section a 
