104 
VETERINARIU8. 
came tumefied towards the end of the first week. The character* 
istic cord-like enlargement of the lymphatics, so common in horses, 
could not be felt. The glands, at first as large as a pea, soon be¬ 
came larger and their parenchyma underwent a purulent degenera¬ 
tion which eventually broke out externally. When this took place 
at an early stage the characteristic bacilli were easily demon¬ 
strated. s The later this happened the fewer bacilli were present. 
In some of the animals no further external phenomena took place. 
In course of time the ulcerations healed and the animals again 
gained in condition. The induced disease assumed quite another 
course in the majority of the animals. The second week after in¬ 
oculation a peculiar complication of the testes was noticed, consist¬ 
ing of small noduli in the testes and epididymis; the scrotum also 
became diseased; the folds of the tunica vaginalis became in¬ 
flamed and adherent to one another and the skin, so that the 
skin could not be moved. The external skin became red and 
odaematous; finally rupture of the noduli occurred, and on pres¬ 
sure a puriform material escaped in which numerous bacilli were 
found. In the females an intense tumefication and ulceration of 
the mamae and labiae developed. These affections are, however, 
under similar conditions, less frequent than orchitis in the male. 
Towards the end of the second week an eruption in the feet 
occurred, which were swollen, red, hot, and very sensitive on pres¬ 
sure. These conditions frequently disappeared in one foot and 
appeared in another; sometimes all four feet were affected ; these 
complications frequently ruptured and gradually healed. Besides 
these very characteristic phenomena of glanders in guinea-pigs, 
local complications of superficial muscles were observed in other 
parts of the body, such as the face, where they developed from the 
periosteum and even complicated the osseous tissue, and sometimes 
caused penetrating ulcers in the nasal bones. The nasal mucosa 
was found diseased in about one-third of the cases, indicated by 
disturbances in the respiratory phenomena, but profuse nasal 
secretion was seldom observed; crusts on the alae nasi were fre¬ 
quent in such cases. When the affection of the nasal muscosa 
occurred it was generally the concluding act of the drama. 
The animals generally perished in the third or fourth week, 
