GLANDERS. 
105 
sometimes the first or second, and occasionally extending to the 
seventh or eighth. The autopsy of such animals gave the follow¬ 
ing conditions: Inguinal and axillary glands tumefied, moist and 
lustrous; on section numerous centres containing a purulent 
material were seen; the whole gland underwent such degeneration 
and became enclosed in a capsule of indurated tissue. Abscesses 
of various sizes were found in the skin, many of which showed a 
tendency to heal. Some of the pedal joints were swollen, caused 
by the development of peri-articular abscesses and which extended 
into the tissues between the digits and often complicated the 
bones. The lungs contained many nodular neoplasms of. various 
dimensions, many of which were surrounded by hyperaemic tissue; 
these noduli became more apparent after hardening in alcohol. 
Ho changes were observed in the heart. The spleen was affected 
in nearly every case and contained numerous greyish-white noduli, 
as also did the liver, but not nearly so many as the spleen. The 
kidneys were free from all neoplasmata and bacilli, and on cross 
section they were normal or slightly clouded in appearance. On 
the other hand the bacilli were found in the urine, their true 
character being determined by inoculation experiments. A few 
isolated noduli were occasionally found in the suprarenal capsules. 
Noduli, many of which had undergone puriform degeneration, were 
found in the omentum, the suspensory ligament of the liver and 
the retroperitoneal tissues. The intestinal tract was normal. 
When the processes on the testicle were of recent date they con¬ 
sisted of submiliary noduli situated in hyperaemic tissue; when 
older they contained large caseous centres, frequenty undergoing 
puriform degeneration or bursting externally. The ovaries of the 
female were not diseased in the same manner, but isolated yellow 
neoplasms were sometimes found. The mammae frequently pre¬ 
sented similar conditions. The nasal mucosa was red, swollen, 
and interspersed with numerous small lenticular ulcerations, fre¬ 
quently extending to or penetrating the underlying osseous tissue. 
The bacilli were easily demonstrated in all the products when 
fresh, in later stages with difficulty, as many of them undoubtedly 
perish when disintegrating processes commence. Fresh pul¬ 
monary noduli are especially useful for bacillus examination on 
