GLANDERS. 
107 
4 in 
23 “ 
9 “ 
8 “ 
4 “ 
1 “ 
2 days after inoculation. 
3 
u 
a 
a 
4 
u 
a 
a 
5 
66 
u 
66 
6 
66 
(( 
66 
7 
« 
a 
66 
1 u 11 “ u i6 
The average duration of the disease being between three and 
four days. The course of the disease was almost always the same. 
The animals appeared perfectly well on the first and frequently 
the second day after inoculation, ate well, ran about and buried 
themselves in the saw-dust of their cages. They then became less 
lively, withdrew from observation or sat in one place, with rough¬ 
looking coats and adherent eyelids, rapid respiration and no appe¬ 
tite ; they were then observed to fall on one side and die without 
any convulsions. The microscopical results were exceedingly 
characteristic but different from those observed in glanders in 
other animals. The locus inoculationis was infiltrated with a 
greenish-gray appearing mass, penetrating the superficial layers of 
contiguous muscles, and from this point lymphatic cords could be 
traced to their appropriate lymph glands, which were hyper¬ 
trophied and more or less filled with greyish-white centres. 
Spleen enlarged and its parenchyma studded with yellowish-white 
noduli, frequently surrounded by a red anulus of distended vessels, 
and superficial neoplasmata were often seen above the surface of 
the capsule. The liver contained numerous small noduli, but they 
did not extend above the surface of the organ. The kidneys did 
not appear to have undergone any changes. The suprarenal cap¬ 
sules and ovaries were frequently the seat of small ecchymoses, 
with occasional yellowish-white nodules dispersed throughout their 
substance or upon their surface. Joint affections were observed 
in five cases, the most common seat being the pedal joint. They 
were swollen hypersemic, and when cut a puriform fluid escaped. 
In one case all four joints were affected. Affections of the skin, 
besides those already mentioned at the locus inoculationis, were 
not observed. The nasal cavity was free from complications. 
Glanders bacilli were found in great numbers in the spleen, lungs, 
