EXTRACTS FROM FOREIGN JOURNALS. 
141 
can be used in cases of the doubtful diagnosis of glanders, the 
following live modes of inoculation are recommended : 
1st. The insertion of solid pieces of virulent matter in a 
fracture made subcutaneously. This is best adapted for glander¬ 
ous granulations or thick pus. 
2d. Deposits of virulent discharges on the dermic surface ex¬ 
posed by the removal of the epidermis with a pair of sharp 
scissors. 
3d. Superficially intercrossed scarifications upon which the 
glanderous discharge is spread. 
4th. Subcutaneous injections, with Pravaz’s syringe, of virulent 
liquid, prepared by the trituration of glanderous matter with dis¬ 
tilled water, with subsequent filtration through fine, clean linen. 
5th. Intra-renous or intra-peritoneal injection of glanderous 
virus. 
The interval before the appearance of the symptoms varies ac¬ 
cording to the quantity of virus used. With large quantities the 
eruption of the local symptoms is rapid, indeed, almost sudden, 
the generalization being also rapid, and death by the acute form 
soon taking place. With small quantities the generalization is 
slow, and death by a sort of chronic process takes place also 
slowly. 
Acute glanders in the guinea pig is fatal in from fifteen to 
twenty-five days, while the chronic form has an average duration 
of sixty days, and the life of the patient may last one hundred 
and thirty-two days. 
MM. Cadeac and Malet say, in conclusion, that to realize all 
the advantages that the cobaye may offer, one must: 
1st. Inoculate with virus as fresh as possible in order to avoid 
septicemia. 
2d. Inoculate two animals at the same time for the same ex¬ 
periment. 
3d. Make the inoculation in several places on the same sub¬ 
ject. 
4th. Inoculate in the flank, in the face when one uses scissors; 
on the internal face of the thigh when it is done with the syringe 
of Pravaz .—Revue Yeterinaire. 
