INOCULATION AGAINST ANTHRAX. 
309 
previous swelling. This was opened in a few days and the pus 
evacuated. A rabbit subjected to the same test died of typical 
anthrax in seventy-eight hours. 
The foregoing cannot be regarded as absolute and in itself 
sufficient proof of the protective power of the Pasteurian vaccine, 
though it is certainly favorable to it. 
2. Our attention was now turned to discover if any reliable 
means obtained by which protection could be secured against 
fatal attacks of that disease recognized as “ quarter-ill.” This is 
particularly an affection of young stock; it is extensively distrib¬ 
uted over Great Britain; it is generally well recognized, and is 
very fatal. From the changes which occur in the soft structures, 
and the rapidity and fatality of its issues, it has for long been 
confounded with pure anthrax. It is, however, now believed to 
be essentially distinct. Both are what are known as microbic 
diseases, i. e ., they owe their existence to the entrance into, and 
growth in the animal tissues of a specific micro-organism. Each 
disease is now recognized to be dependent for its existence upon 
its own individual microbe. 
Before proceeding to test the efficacy of certain modes of pre¬ 
ventive inoculation which had been stated to be effectual by the 
French experimenters, MM. Arloing, Cornevin and Thomas, we 
determined to satisfy ourselves of the asserted contagiousness of 
this malady. This was demonstrated to our satisfaction, by in¬ 
jecting one drop of muscle-juice from an animal which had suc¬ 
cumbed to the disease, into the subcutaneous tissue of each of 
two guinea-pigs, and five times this amount of the same material 
into the haunch of a young bullock. The guinea pigs died from 
quarter-ill in ten and a half and thirty-six hours, respectively, the 
ox in thirty-seven and a half hours. Muscle juice from the local 
lesions of all these cases proved, by further testing, that it con 
tained the specific microbe. 
Having considered and examined the several accredited ex- 
perimental modes said to afford protection against this disease, 
two were selected for trial as more likely than the others to yield 
the wished-for results. The first which we took up was that of 
employing the dried muscle-juice of the local lesions of the dis- 
