PHYSIOLOGICAL PATHOLOGY 
419 
PHYSIOLOGICAL PATHOLOGY, 
UPON THE VARIABLE DURATIONS OF THE DEVELOPMENT OF 
TUBERCULOUS. 
By M. G. Darenberg. 
Pare cultures of tuberculosis bacilli, prepared by the process 
of Nocard and Roux, kept at 38° and inoculated in rabbits by 
trephining, kills them in from 21 to 30 days, with the ordinary 
symptoms of human tuberculous meningitis, such as hemiplegia, 
blindness, deafness, etc. The thickened meninges are infiltrated 
with pus full of bacilli, which are also found in the liver, without 
other microscopic lesions. Guinea pigs inoculated by trephining, 
die in 20 to 50 days with bacilli in the liver and the spleen, but 
almost always without microscopic lesions. These same cultures 
inoculated per cranium to hens or pigeons kill them in six or 
seven months, with the lesions of tuberculous meningitis. 
A pure culture of tuberculous bacilli, kept at 15°, after com¬ 
plete development, inoculated by trephining to a very strong 
rabbit, has produced a cold abscess on the summit of the cranium, 
which made its appearance ten months after the inoculation. The 
animal lived in perfect health with that abscess four and a 
half months and was afterwards killed. The pus on the walls of 
the abscess, which was as large as a pigeon’s egg, contained bacilli, 
but the other organs contained none. Guinea pigs and rabbits 
two and three months old, inoculated with pus taken from this 
animal during life, died with tuberculosis in from twenty-four to 
thirty days, while large rabbits, inoculated with the same pus, did 
not, four months after, present any morbid symptoms. This fact 
seems to confirm the experiments of Arloing, who has seen 
scrofula produce tuberculosis in young but not in adult rabbits. 
The marrow of animals dying with tuberculous disease con¬ 
tains a few bacilli. We have seen marrow which had been dried 
twelve days before with chloride of lime, kill a guinea pig in 
140 days, with tuberculosis of the spleen, liver and omentum. A 
portion of marrow which had been dried nineteen days killed a 
guinea pig in 200 days with pulmonary tuberculosis. 
