FOOT-AND-MOUTH DISEASE. 
441 
in the mouth, and an itching in the hands and fingers. These 
symptoms continued about five days. Then the entire mucous 
membrane of the mouth began to swell considerably, especially 
that of the tongue, upon w T hich organ, particularly the edges of 
it, and also upon the inner surface of the cheeks and lips, there 
appeared small vesicles, never larger than a lentil, of a yellowish- 
white color, and filled with turbid whitish contents which were 
readily discharged when the vesicles were pricked, but were soon 
reproduced. Upon the following days the vesicles became still 
larger and burst; the epithelium was then detached, leaving be¬ 
hind dark-red erosions which gradually healed. There was, con¬ 
joined with the above symptoms, a smarting pain in the mouth upon 
the attempt to masticate, speak or swallow, and also an intense 
thirst. The vesicles upon the lips dried up, leaving in their places 
thin brown scurfs, which upon the tenth day after the appearance 
of the former fell off. Simultaneously with the development of the 
eruption in the mouth, numerous vesicles were formed upon the 
hands and fingers, which at first were of the size of a millet-seed, 
firm, and of a yellowish-white color, but in their further progress 
approximated in look to those in the mouth, healing, however, 
more slowly. At the termination of this process he was restored 
to the best of health.” Two other physicians performed the same 
experiment upon themselves, with the same result as obtained in 
the case of Hertwig, except that they had no eruption of vesicles 
upon their hands. The symptoms thus produced by drinking 
fresh milk containing the contagium of the disease under con¬ 
sideration, vary somewhat from those produced by inoculation of 
the human subject with the contents of the vesicles, at least in 
some instances. That this is true will be shown in the record of 
r 
the following cases: 
About the end of August,* Mrs. X-, wife of an extensive 
farmer, came under my care on account of an eruption of bright 
red spots , one-eighth of an inch in diameter (covered with a thin 
white desquamation), which were so densely sprinkled over her 
body as to leave only minute interspaces of sound skin. As Mrs. 
X-had within the last three years suffered from hepatitis with 
^Edinburgh Medical Journal, 1863, Hislop. 
