.T. W. STICKLER. 
442 
jaundice, I thought the eruption might be thus originated. Al¬ 
terative purgatives made no impression upon the disease. 
On a subsequent visit I found her husband complaining of a 
sore throat and mouth. Upon examination found the mucous 
membrane of his mouth, lips, tongue, and throat studded with 
small ulcers, giving off a white slough, which left behind a clean 
but highly sensitive cup-shaped cavity. His forehead was covered 
with an eruption similar to that upon the lower extremities of his 
wife. The eruption was never vesicular as it is in cattle. The 
spots made their appearance as slightly elevated, reddish promin¬ 
ences (papulae), which gradually become bright red, then threw 
off a silvery-white scale, and gradually disappeared. Mrs. X- 
had slight inflammation of the fauces. Some of the children 
about the house were also affected with sore throat, but the symp¬ 
toms in these cases were very mild and easily overcome. At the 
time this disease affected the above patients the whole of Mr. 
X-’s cows had murrain. Mr. X-says that, when examin¬ 
ing one of the cows which was suffering from the disease, and 
while in the act of pressing back the lip, he observed two or three 
pimples on the upper lip to burst and eject the matter to a con¬ 
siderable distance, and that he received a portion on his cheek and 
hand. Both parties, as well as those affected in a lesser degree, 
had gone freely about the byres, handling the diseased cows, of 
which there were at times upward of a dozen ill at once, and the 
peculiar virulence of the symptoms in Mr. X-’s case seemed 
to depend upon the circumstance that the matter caught upon his 
hand and cheek was derived from one of the worst of the diseased 
animals. 
The epidemic of “ sore throat” which occurred at Dover, 
England, in 1884, furnishes still greater opportunity for the 
study of “foot-and-mouth disease” as it affects man* “During 
the early days of February, 1884, a remarkable outbreak of 
sore throat occurred in Dover, England, which, on account of the 
suddenness of the outbreak, the severity of the symptoms, and its 
chief prevalence among those occupying the best houses in the 
town, attracted no small amount of public attention, and naturally 
♦Quoted from the official report of the epidemic. 
