488 
J. W. STRICKLER. 
a fluid pus mixed with epithelial cells, which in drying forms a thin 
reddish crust that protects the erosion until it heals. In the 
mouth and on the lips the vesicles are broken almost as soon as 
formed, leaving circular or irregular bright-red sores which bleed 
readily, their rupture being indicated by dribbling of saliva 
streaked with blood, 
It sometimes happens that rohen the tongue is seized to explore 
the mouth , large patches of epidermis come away in the hand , as 
if the tongue had been boiled. In some rare cases an exudation of 
yellow color and cheesy consistency is observed toward the root 
of the tongue, due to epithelial proliferation. 
The fever has greatly subsided, but the thirst is intense, and 
the animal eagerly drinks water or gruel, though, owing to the 
soreness of the mouth, it can eat but little, especially if the food 
be dry and hard ; consequently the loss of condition is rapid. 
Fourth Period. This is marked by the desiccation or drying 
up of the aphthae, and the formation of new epidermis. The crust 
falls off, and new epidermis or epithelium appears as a thin lead- 
colored pellicle. There is also at this time a general desquamation 
of the cuticle, and this is invariably the case. There is also a good 
deal of itching of the surface (Walley). With the completion of 
these processes all traces of the disease disappear. There is no 
lameness, the appetite has returned, and the former condition is 
being restored; while the secretion of milk, which may have been 
greatly diminished—perhaps to less than one-third—becomes aug¬ 
mented, and regains its normal properties. 
* Bollinger states that “ in animals which have once acquired 
the disease the susceptibility ceases for a considerable period, or 
at least becomes very slight. .Repeated attacks of the malady in 
the same animal are, upon the whole, rare.” That the susceptibility 
ceases for a time has been demonstrated by Dr. E. Klein, of London, 
England. He inoculated five sheep with active cultivations of the 
micrococcus, but without producing any definite local or general 
lesion. “ Subsequent feeding of these same sheep with the active 
micrococcus had no result.” From this he argues that a previous 
subcutaneous inoculation with the micrococcus provides the ani¬ 
mals with immunity against the disease, Dr, Klein also claims 
