490 
.T. W. STRICKLFJR. 
ted together. Subcutaneous inoculation with artificial cultivations 
produces no perceptible disorder, but by feeding sheep with a 
twentieth generation the typical disease has been reproduced, viz., 
vesicles and ulcerations upon the feet. From the vesicles of such 
animals lymph was obtained which, on cultivation, yielded the 
same micrococci, characterized by the same slow growth and the 
same typical appearance as those used for the experiment. Dr. 
Klein claims, therefore, that there can be no question about the 
identity of this peculiar micrococcus with the cause of the disease. 
The description thus given of the mode of growth and appear¬ 
ance of the micrococci of foot-and-mouth disease does not mater¬ 
ially differ from that given, by the same investigator, of the 
micrococci found in the ulcers of cows affected with a disease 
which has since been determined to be cow scarlatina. For the 
sake of instituting a comparison, I will quote his own words with 
reference to the cultivation and appearance of the bovine scarla¬ 
tinal streptococcus. 
“ From the deeper parts of an ulcer of cow IV. (one he had 
under observation) material was obtained, with which tubes con¬ 
taining either solid nutritive gelatine or agar-agar mixture were 
inoculated. After some days, and in both media, a micrococcus 
appeared, the growth of which was extremely characteristic. 
These are its characters in the nutritive gelatine: After three to 
six days’ incubation at 20° C., the growth made its appearance at 
the point or line of inoculation, in the form of small points or 
granules, whitish in color, and tolerably closely placed. During 
the next few days their number and size increased. At the end 
of a fortnight the line of inoculation was visible as a streak of 
whitish granules or droplets, some large, others small, more or less 
closely placed. On the surface of the gelatine the growth, like 
a film of granules, spreads slowly in breadth, but even after months 
remain small. When inoculated into the depth of the gelatine 
the channel of inoculation becomes visible as a whitish streak, 
made up of smaller and larger droplets. The gelatine is not liq¬ 
uefied by the growth. The same characters are assumed by the 
growth in agar-agar mixture, and in solid serum. The general as¬ 
pect of the growth in gelatine, in agar-agar, and in scrum, is very 
