FOOT-AND-MOUTH DISF.ASE. 
493 
the temperature began, or continued to rise till it reached 103J° 
F., at 8 p.m., May 13th. The temperature then began to fall, till 
it stood at 101J° F., May 16th, at 3 p.m. During this time the 
intermaxillary glands became enlarged and sensitive, the mu¬ 
cous membrane of the nostrils and eyes injected, and from the 
nostrils there was a discharge of ropy mucus. Thinking that the 
injury received on the 12th might have interfered with the natu¬ 
ral action of the virus by causing a local inflammation and a gen¬ 
eral rise of temperature, and wishing, if possible, to intensify the 
effect of the first inoculation, I injected into the jugular vein some 
pharyngeal mucus from two well-marked cases of scarlatina. The 
result was an increased redness of the mucous membranes of the 
nose and mouth, and a mild sore throat, which disappeared with 
fading of the redness of the mucous membranes. The symptoms 
above given almost entirely disappeared by May 24th. There was 
no subsequent oedema of the extremities or sheath, nor was there 
any desquamation of the cuticle. 
On June 28,1883, I enveloped the head of a perfectly healthy 
colt in a bag containing a chemise which had been worn by a 
scarlet fever patient. This I allowed to remain adjusted about 
seventy-two hours. On July 2d I injected into the left jugular 
vein, and into a vein in the leg, some human scarlatinal blood. 
Within forty-eight hours the temperature began to rise, the colt 
became less active, showing a tendency to remain quiet. On the 
sixth day (July 8th) she began to cough and swallowed with dif 
Acuity. The visible mucous membranes were quite red, and at 
certain points had somewhat the appearance of the mucous mem¬ 
brane of the pharynx in man when affected with scarlet fever. 
The intermaxillary glands were enlarged and sensitive, and, when 
the throat was pressed upon, the colt evinced uneasiness. There 
was a discharge of tenacious mucus from the nostrils. The phar¬ 
ynx was unnaturally red. On July 9th I introduced some epider¬ 
mal scales, obtained from a scarlet-fever patient, under the skin of 
the abdomen, but so far as I could determine they produced no ef¬ 
fect. In this case there was a desquamation of the skin at a few 
points where I had not previously seen an eruption. 
In both colts there followed the inoculations, sore throat 
