494 
J. W. STKICKLER. 
ness of the mucous membranes of the nostrils, mouth, and pharynx, 
elevation of the temperature above normal, and in one, desquama¬ 
tion of the cuticle. It seems reasonable, therefore, to believe that 
a specific disease was produced in both instances, and that the 
specific disease was scarlatina. Since that time I have inoculated 
rabbits, dogs, guinea-pigs and cattle with human scarlatinal mat¬ 
ter, and have obtained some very gratifying results, especially in 
cattle. In May, 1883, I inoculated a calf with human scarlatinal 
virus by injecting into the general circulation some blood taken 
from a well-marked case (a young man with a typical eruption on 
neck, chest, abdomen and limbs), and by subcutaneous introduction 
of the blood into the abdomen. After the lapse of a few hours 
the skin at and near the point of inoculation (abdomen) became 
uniformly reddened. The elevation of temperature was very 
slight. The redness and sensitiveness of the skin increased until 
May 24th, when I discovered pus at the centre of the area of red¬ 
ness. The temperature at that time was 1021° F. The visible 
mucous membranes were not affected, fiecovery complete by 
Jnne 1st. 
Knowing that cows recently calved were supposed to be espec¬ 
ially susceptible to scarlatinal contagium, I procured one that had 
aborted about one week prior to the time of purchase. 1 inocula¬ 
ted this cow in the udder with some pharyngeal mucus taken from 
a patient sick with scarlet fever. The day following the inocu 
lation the temperature rose to 102° F.; pulse 48. On the third 
day the temperature was 102f F.; pulse 56. The temperature 
then began to descend till it reached 101£° F. on the eighth day. 
During this time a cough developed, and it was noticed that the 
animal did not swallow with the same readiness as usual. At the 
point of inoculation had developed a superficial vesicle, which very 
soon became filled with purulent contents. Still deeper in the 
tissues a small abscess formed, which, after discharging its contents 
remained open, discharging a small amount of pus. The skin 
around the seat of the vesicle'and abscess was quite intensely red¬ 
dened. The temperature gradually declined, till finally, on the 
nineteenth day, it fell to 100J° F. There was a desquamation of 
the cuticle near the ’abscess where the skin had been reddened, 
