FOOT-AND-MOUTH DISEASE. 
495 
The next cow I inoculated was in the third or fourth month of 
gestation. The inoculation was made in the udder, and with 
pharyngeal mucus from a typical case of human scarlatina. 
Twenty-four hours after the inoculation the temperature began to 
rise, although slowly. On the second day the thermometer 
showed a temperature of 101J° F.,and it did not vary from this 
point till the seventh day, when it fell to 100° F. During this 
time the udder became reddened, swollen and tender, and finally 
suppurated at the point of inoculation. After the pus, which was 
small in quantity, was allowed to escape, the cavity of the abscess 
continued for a few days to discharge pus and then gradually 
healed. There was no sore throat, nor alteration of the mucous 
membranes. The reddened integument of the udder around the 
abscess desquamated. A subsequent inoculation of this cow with 
human scarlatinal virus produced no effect. 
I next inoculated a calf with pharyngeal mucus and epidermal 
scales derived from scarlatinal patients. The inoculation was 
made in the abdominal region. At the point of inoculation there 
very soon appeared a vesicle about as large as a lima bean, which 
was at first quite clear, but later became filled with sero-purulent 
matter, and then became yellow in appearance. Coincidentally 
with the development of the vesicle there was an elevation of tem¬ 
perature, and the appearance of an intense reddness of the skin 
for some distance from the point of inoculation. There was no 
sore throat. As I wished the contents of the vesicle as a virus 
with which to inoculate some children, I punctured it, collecting 
the fluid in a small bottle. After being punctured the vesicle be¬ 
came converted into an ulcer, which gradually healed. The skin 
near this vesicle desquamated after the redness disappeared. I 
am led to believe, as a result of what I have seen while experi¬ 
menting thus with cattle, that it is possible to infect them with 
human scarlatinal contagium. 
To answer the second question, I may say that, so far as my 
experience serves me, the lesion produced in the lower animals by 
inoculation with human scarlatinal virus is a mild one. I am 
aware, however, that it might be otherwise. 
In a recent letter, Dr. E. Klein, of London, England, whose 
