FOOT-AND-MOUTH DISEASE. 
497 
I lmve found that results 1 obtained in several instances are 
greatly strengthened by the recent experimental investigations of 
Dr. Klein as to the nature cf the Henden cow disease, and its 
connection with the outbreak of scarlet fever at South Marylebone 
and in a certain district in London. The vesicles upon the udder 
of the cow and the abdomen of the calf already alluded to, as well 
as the general course of the disease, as occasioned by inoculation 
with human scarlatinal virus, correspond witli the description of 
the disease as seen in England. 
The answer to the third and most important question may per¬ 
haps be suggested in what follows : 
In the early part of the year 1883 I inoculated twelve persons 
with virus obtained from horses supposed to have scarlatina. 
Since that time not one of that number, so far as I can learn, has 
had scarlet fever. These twelve persons were also inoculated with 
human scarlatinal blood after they had been inoculated with 
equine virus. During the summer of the same year I inoculated 
thirteen children, all of whom had been, and were at the time 
of inoculation, exposed to the influence of air contaminated by 
the breath and exhalations of scarlatinal patients. Five of this 
number escaped, the remaining eight developed the disease (scar¬ 
latina) very soon after inoculation, in one instance within five 
hours. Four of the eight cases had no angina, but simply the 
eruption, with slight disturbance of the stomach. They were not 
confined to bed one hour. None of the cases were severe. 
During the last year I have inoculated two children with the 
contents of a vesicle produced in the abdomen of a calf by inocu¬ 
lation with virus derived from a patient who had scarlet fever. 
The notes of the first case are furnished by Dr. Stubbert, of 
Bloomfield, N. J., who watched the patient from day to day after 
the inoculation. “ On April 25th the child was inoculated in the 
left arm with scarlatinal matter taken from a calf. On the 27th 
an erythematous blush appeared about the scarification. By the 
28th the blush had disappeared, but a scab had formed, and around 
its puffed-up border there was a red areola. On April 30th the 
child had quite a high fever. On May 1st there appeared on the 
upper part of the chest a rash similar to a scarlatinal rash. On 
