THE PATHOLOGY OF AZOTURIA. 
179 
3d. A further increase of the solid constituents of the 
blood from the accumulation in it of the products of tissue 
waste, the result of muscular exertion, and a still further 
deprivation of water concentrating the blood to an extent 
which can no longer be regarded as physiological but as 
essentially pathological. 
A careful study of the symptoms suggests a very similar 
condition to that outlined. 
The evident vigor of constitution, the powerful muscular 
development, the want of excessive fat and the remarkable 
show of eagerness and strength just prior to the attack ol 
azoturia, is strongly suggestive of hyperalbuminosis. 
The absence in animals subject to azoturia of oedematous 
(hydrcemic) swellings of the limbs, lower parts of belly, 
sheath, &c., so common in animals at rest, not subject to the 
disease, constitutes strong evidence of the decrease in the 
humidity of the blood. 
Finally, when sudden muscular exertion changes the con¬ 
dition from a physiological to a pathological state, the morbid 
symptoms are in many respects closely allied to the symptoms 
produced by sudden blood concentration and loss of its 
humidity, as is observed in the cramp and muscular spasms, 
in severe hemorrhages, in certain stages of cholera, and more 
rarely in severe drastic purgation. 
The highly colored urine, with its contained haemoglobin 
urea, uric and hippuric acids, is strongly suggestive of the 
destruction of the red blood globules, perhaps also of the 
muscle corpuscles; and their conversion into these less com¬ 
plex bodies can in no way be more surely and promptly 
brought about than by suddenly withdrawing from the blood 
and other tissues an amount of water beyond the physiological 
limit, as this excessive concentration and dryness means blood 
stasis; and unless the humidity is quickly restored, they point 
to destruction of the red globules or of the similar muscle 
elements. 
Remembering, as has been demonstrated, that the quantity 
of blood in muscular tissue, during severe work, is increased 
by about eighty per cent, over the amount contained in a 
