192 
PAUL GIBIER. 
make the following - remark, that whereas the lad complained 
only of local sensibility, of fatigue, and of a little nocturnal 
agitation, we, who are more accustomed to observations, made 
several which I think are worthy of record. 
The series of inoculations which I practiced on myself and 
on my two aids began March 27, 1890, with matter of the 
14th day, and ended on the 10th of April following, with the 
matter of the second day. 
The subcutaneous injections of the first four days were 
followed by a slight irritation, which in one of us extended as 
far as the redness of the tegumentum in loco , but without in¬ 
duration. During the night sleep was somewhat disturbed 
by the sensitiveness of the lateral part of the lumbar region, 
viz., at the spot of the inoculation. During the first ten days 
the symptoms were about the same. The temperature of the 
body rose slightly, but it cannot be said whether this slight 
febrile motion was caused through and by the injected matter, 
or whether it was the result of the slight inflammation caused 
by the injection itself. Those symptoms were considerably 
modified by hot baths of lengthy duration. Towards the 
tenth day the tissues seem to have accustomed themselves to 
the injected liquid; the reaction was less acute, the pain de¬ 
creased, and three days after the last injection there remained, 
so to speak, hardly any local trace of the fifteen injections 
made on each side. 
Thus far I have not said anything to explain the working 
of the immunity, but f will now take up the subject. How, 
then, is immunity obtained? In a book I published last year 
(Analyse des Choses —Dentu, publisher, Paris), I propound a 
theory, which, according to my belief, may be of use to ex¬ 
plain this hitherto mysterious property, common alike to men 
and to animals, of resisting the inroads of certain diseases 
when once attacked by them. In the living body, what is 
there that resists the development of the infectious figurated 
element which has reached the body from the outside? Evi¬ 
dently it is the figurated elements which make up that body; 
in other words, it is the living cell. For me, immunity is a 
phenomenon of cellular memory. The cellulas are small in- 
