348 
DR. FROHNER. 
i. As an antiparasitic for epizoa. Of all ectoparasites the 
mites of scab, especially of the class of sarcoptes, are the most 
difficult to destroy. The importance of these parasites as re¬ 
gards national economy is most apparent in scab of sheep 
(Dcrmatodectes ovis) which alone causes Germany a loss of 
several millions of marks ever}^ year (thus in 1884 nearly 250,- 
000 sheep were found to be infected in Germany alone). In 
the dog likewise, mange, due to the presence of sarcoptes, also 
causes extensive losses. Of the animals brought to the Hos¬ 
pital of Dogs in the Berlin Veterinary School during the year 
1886-1887 no less then 639 of the whole number (8,399 i n a ^) 
were found to be suffering from this malady, or, in other 
words, over seven per cent, of all dog diseases in Berlin come 
under this heading. The remedies usually applied for mange 
are carbolic acid, arsenic, corrosive sublimate, tobacco, and 
balsam of Peru, besides alkaline medicaments. The last, as 
also the first three, are violent poisons, and a large number 
of mangy dogs yearly succumb to the effects of treatment 
with them. A cheap subs'ance equalling carbolic acid in its 
action, without being possessed of its poisonous properties, 
would therefore be considered the beau ideal of a remedy for 
mange. To all appearances it has been found in creolin. In 
none of my numerous experiments was there the least trace 
of toxical (i. e. poisonous) symptoms to be observed. The dogs 
experimented on received at first 1 gramme (=15.432 grains), 
then two, five and eventually fifty grammes of pure, undiluted 
creolin internally, without evincing the slightest change in 
their general state of health. The same result was observed 
in horses similarly treated. This proves that neither when 
absorbed through the skin, nor even if licked off by the ani¬ 
mals themselves, does creolin exert any detrimental effects. 
In order to draw comparisons between the results achieved 
by balsam of Peru and the effect produced by creolin, I caused 
six dogs affected with this malady to be inuncted on one-half 
of their body witfc the former, on the other half with the 
latter medicament. The effect of both seemed the same. But 
whereas the expense of treating a dog with balsam of Peru 
was 10 marks (ten shillings), the cure was effected by means 
