636 
RICHARD MIDDLETON. 
a phlegmonous infiltration the size of a hen’s egg ; this patient 
recovered in a short time. With the same result were those 
dogs inoculated with chicken ciiolcra cultivations. 
At the same time and with the same material, a foal was 
injected ; after some time there developed a large painful and 
warm swelling of the skin and subcutis of the whole lateral 
surface of the neck; in a few days this disappeared and the 
filly remained sound. 
Two pigs, respectively three and four months old, on the 
contrary, were less able to withstand the effect; one of 
these was inoculated on the 17th of March upon the flat 
of the thigh, with a drop of blood from the heart of an 
infected rabbit (the latter inoculated from calfs spleen); the 
next day I observed a diffuse, bluish-red, cedematous swelling 
at the injection point and this was accompanied by fever and 
lassitude. On the second day the swelling extended anteriorly 
along the abdomen and inside of the limbs ; this was character¬ 
ized by a dark, cyanotic, erysipelatous appearance. The sub¬ 
ject lay quiet and slept, but ate nothing. After some days the 
general condition was improved, the oedema had disappeared 
and in its stead two hard swellings five inches in diameter ap¬ 
peared ; on the twelfth day fluctuation could be felt. Follow¬ 
ing the incision a quantity of whitish pus escaped, containing 
necrotic debris of connective tissue and muscle. The ovoid 
bacteria were found in the contents, but not in so large quan¬ 
tities ; a mouse was inoculated with portions thereof, and died 
in three days ; at the examination the characteristic pathologi¬ 
cal alterations were present. The other pig became affected 
in precisely the same manner, and showed the same cadaveric 
changes. A third pig was fed with the intestines of an in¬ 
fected rabbit, but with negative results. 
On the 6th of July a rabbit was injected with an agar cul¬ 
ture (17th generation from spleen of calf) and the next morn¬ 
ing was dead ; a few drops of the heart-blood of the same was 
mixed with 6 ccm. of sterilized water, and injected into the 
neck of a bull calf four to five weeks old. Immediately after the 
temperature stood 101.3 0 F.; on the 8th at nine o’clock, about 
fourteen hours after, the temperature was 103.8°, pulse 82 and 
