638 
RICHARD MXDDLETOH, 
whole intestinal track was inflamed and maculated with 
hemorrhages of various sizes. Mesentery glands swollen and 
infiltrated with blood ; the remaining lymph glands of the ab¬ 
domen were in the same condition. 
In the blood and liver somewhat fewer bacteria were found 
and were smaller than those found in the rabbits. They were 
particularly numerous in the oedema fluid, spleen and kidneys. 
Two rabbits and four mice were inoculated with the blood 
and portions of the organs, with a fatal result after a few days. 
About 60 ccm. of the heart-blood, with 200 ccm. of milk, 
were given to another calf; temperature 101.7 0 , the next day 
temperature 103. i° but the general health was not disturbed ; 
the calf received no sort of solid food and was not affected by 
the drench. On the fourth day this same patient received an 
injection of agar culture upon the side of the neck, tempera¬ 
ture 102.2 0 ; the following morning was dull and would take 
no nourishment; temperature 105.9 0 . Eight o’clock the same 
evening a swelling of the size of one’s palm was noticed ; tem¬ 
perature 103.5 0 ; general condition better and a quantity of 
milk injected. The whole region was swollen and doughy in 
consistency, painful and warm; great depression; in another 
• 
day swelling subsided to some extent and health further im- " 
proved. After thirteen days there was a medium sized ab¬ 
scess upon the point of injection, which upon being evacuated 
and the contents examined, showed the ovoid bacteria in the 
pus, and the latter when injected into a rabbit, causing death 
in twenty-two hours. A guinea-pig was also inoculated sub- 
cutaneouly and died after eight da}^s, of a malignant phleg¬ 
mon. 
Thus we see that the same organism which killed calves 
in one to two days; killed rabbits in twelve to sixteen hours 
through a septicaemia, and the guinea-pig through a progres¬ 
sive phlegmon associated with degeneration of the connective 
tissue; pigeons which had been injected in the pectoral mus¬ 
cles developed only small necrotic spots; of seven chickens 
inoculated only one died, and that after eleven days illness ; 
the dissection showed necroses of skin and muscles upon one 
wing (point of injection) and small necrotic portions that 
