A NEW PARASITIC DISEASE OF CATTLE. 
639 ' 
reached from the surface to the deeper interstitial substance 
of the liver. From the liver and blood agar-agar cultures 
were made which when later injected into rabbits and mice 
gave positive results. In all the other chickens the sole in¬ 
fluence of the injection was local, and consisted in circum¬ 
scribed measures which were so extensive that one to two 
months were required to heal. 
Bringing the results together we perceive that only in 
calves (horned cattle ?) mice and rabbits, the disease or rather 
the bacteria cause an acute and contemporaneously fatal septi¬ 
caemia; in other animals they cause, as a rule, only local pro¬ 
cesses. The various animals experimented upon, when ranged 
in order respecting their reception of the virus, are as follows: 
rabbit, mouse, calf, swine, guinea-pig, chicken, pigeon, horse 
and dog. 
Through this order of transmission we obtain a means of 
differentiating the disease from others earlier known, and 
somewhat similar. Chicken cholera is most severe in its 
effects upon poultry ; the swine plague (German) separates it¬ 
self from this affection by its affinity for swine; cattle plague 
selects for its victims our large herbiverous animals. Our 
disease in some degree covers Poel’s pleuro-pneumonia, and 
yet does not exactly; some of our cases develop more 
rapidly and are not found with pulmonary lesions ; as regards 
the manner in which the two diseases affect swine we find 
that the Holland disease induces symptoms simulating swine 
plague, while our disease had no such effect. 
As already remarked, we are inclined to consider all these 
diseases as so many varieties of manifestation of one cause ; of 
one organism. In order to determine this question I made 
the following experiment. The six hens which had with_ 
stood the influence of calf virus, were vaccinated at the expira.. 
tion of four to six weeks, with virulent chicken cholera cul¬ 
ture. It was my purpose to see in how far the chickens were 
proof against chicken cholera. Provided the two diseases 
were only different as regarded virulence, i. e., provided they 
were due to one and the same cause, we should naturally and 
logically expect the six chickens proof against chicken chol- 
