EXPERIMENTAL PATHOLOGY. 
701 
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EXPERIMENTAL PATHOLOGY. 
TUBERCULOSIS—A MODE OF TREATMENT AND OF INOCULATION. 
By Messrs. J. Granohek and H. Martin. 
A sealed envelope, laid before the Academy of Medicine 
of Paris by the authors on the ioth of November, 1889, con¬ 
veyed a statement of the discovery and test of a mode of 
treatment which had proved successful in arresting for a 
long time the development of experimental tuberculosis in 
rabbits. 
The publicity given to the treatment discovered by Dr. 
R. Koch, by which a similar result had been obtained in 
guinea pigs, has made it necessary for the French investiga¬ 
tors to make their researches public sooner than'they had an¬ 
ticipated or intended. 
The rabbit was selected for their experiments, and the in- 
tra-venous injection as the method of inoculation, as being the 
surest mode of obtaining with certainty a tuberculosis which 
produces death within a short and comparatively uniform 
period, with constant characteristic lesions in the liver, spleen 
and lungs, and which is refractory to any local treatment. 
Tuberculosis, when thus developed, proving uniformly fatal, 
a solid basis was thus secured for an accurate, determination 
of the results, whether positive or negative, of the treatment 
which might be adopted for the purpose of producing a re¬ 
fractory condition in the patient, or of effecting a cure after 
the administration of the infection. 
1 st .— Treatment of experimental tuberculosis after infection: 
All the experiments were conducted upon an invariable 
and uniform plan, the rabbits treated, or witnesses, being in¬ 
oculated together in the vein of the ear, with the same quan¬ 
tity of a virulent culture, diluted in a little sterilized water. 
The weight of the animal was taken every day, and served as 
a guide in the application of the treatment. During the last 
two years 42 rabbits were experimented upon, 27 treated and 
15 as witnesses, in various series. The results obtained, gen- 
