702 
EXPERIMENTAL PATHOLOGY. 
erally considered, were similar to those of the following- series, 
in which the treatment proved efficacious in all the rabbits 
treated. 
December 31, 1889, seven rabbits were inoculated in the 
vein of the ear with the same quantity of a very virulent cul¬ 
ture. The witness rabbit died 23 days after the inoculation, 
5 of the treated rabbits lived 126, 176, 176, 184 and 189 days 
respectively, and the sixth rabbit was living 229 days after 
the inoculation. The result of the post-mortem of the dead 
was almost negative. The spleen was small, and the liver 
seemed healthy and without bacillus. But the portal peri¬ 
lobular spaces contained some embryonic cells, marks of a 
tuberculous process in the way of recovery. 
2d.—Inoculation against experimental tuberculosis. 
Viruses were prepared, graded to such a degree that even 
the point of loss of virulency could no longer be detected. 
This scale, however, has nothing in it of a mathematical char¬ 
acter, although it is as capable of being utilized as are those 
of the dried spinal cords in the Pasteur treatment of rabies. 
Virus No. 1, which is the strongest of the series, is fatal 
when administered to the rabbit by intra-venous injection, in 
from fifteen days to a month. Numbers 2, 3, 4, 5, 6, 7, 8,9 
and 10 are successively weaker. Cultures from viruses 10 to 
7 inclusive do not increase in strength, and produce no ef¬ 
fects on rabbits. Viruses Nos. 2 and 3 are fatal, but take 
effect at various periods of time, according to the resistance 
of the animal. The effect is, of course, similar with viruses 
4, 5 and 6. One of the first experiments dates back to August 
27th, 1887, on which day five rabbits received, in the vein of 
the ear, half of a Pravoz syringe each of No. 6, a very weak 
culture. September 3d the same rabbits received virus No. 
3, and on the 12th of the same month a second dose of the 
same virus; September 26th virus No. 2, and on October 
15, virus No. 1 ; three other rabbits being on the last date in¬ 
oculated as witnesses, and dying respectively on the 28th of 
October and the 2d and 5th of November, with all the char¬ 
acteristic and authentic lesions of experimental tuberculosis, 
