EXPERIMENTAL PATHOLOGY. 
703 
to wit, enormous spleen, colored liver and lungs filled with 
tuberculous granulations. Three others of those inoculated 
also died with similar lesions. The other two resisted, one 
until December 17th, the other until January 7th, 1890. Both 
of these had very slight tuberculous lesions. Some little 
benefit being thus realized by these first experiments, notwith¬ 
standing the insufficiency of the inoculation, which consisted 
only of the weakened cultures of viruses 6, 3, 3 and 2 before 
the very virulent inoculation, a new series was made with an 
increase in the number of inoculation cultures, stopping with 
virus No. 2. Good results were thus obtained, especially in 
a series of nine inoculated and two witness rabbits ; five of 
those inoculated on the 25th of January with a culture of 
virus No. 2, being still alive seven months later. 
But when stopping with virus No. 2, the witnesses did not 
all die at the same time, and the immunity secured seemed 
less obvious. In a last series then, 11 rabbits received from 
January 30th to March 25th, cultures of viruses Nos. 6, 5,4, 
3 and 2, and on the 10th of April these 11 rabbits were inocu¬ 
lated with virus No. 1, two witnesses also receiving the same. 
These two died on the 3d and 10th of May, or 23 and 30 days 
after the injection. The 11 inoculated resisted longer; two 
died on the 16th and 26th of June; two on the 7th and 29th 
of July ; four on the 4th, 7th and 9th of August, and three 
were still living four months after receiving the most virulent 
inoculation. 
Conclusion. —The result established, first , a prolonged re¬ 
sistance in rabbits to the most rapid and most certain experi¬ 
mental tuberculosis ; and again, second , an immunity in re¬ 
spect to the same disease, the duration of which yet remains 
to be determined. 
The results obtained by Dr. R. Koch on guinea pigs were 
probably obtained by different methods and processes, at least 
so far as the inoculation is concerned, and so long as no allu¬ 
sion is made to it in his published announcement, we are jus¬ 
tified in hoping that there will some day be a diversity of 
methods known for the treatment of tuberculous bacillus,—* 
Academic des Sciences , 
