EDITORIAL. 
267 
central part, lightly colored, surrounded by a peripheric zone 
scarcely tinted and forming a kind of sheath. These corpuscles 
are sometimes arranged by series of two. They present a kind 
of prolongation or flagellum. 
According to L. V. Betegli, these are the specific agents of 
aphtous fever. 
* 
* * 
Transmission of foot-and-mouth disease to human beings is 
generally admitted, and if direct inoculation has been successful, 
the reinoculation from man to bovine had never been realized. 
An Italian doctor, E. Bertarelli, is the first who realized the ex¬ 
periments of a. reinoculation to bovine with aphtous virus taken 
from man, so records Panisset from the Centralbl. f. Bakl. 
The disease prevailed amongst a large number of bovines. 
The disease was mild. Some people caught it. One man was 
inoculated in opening the mouth of sick animals. He had a few 
days later cephalalgy, soreness all over, painful sensation in the 
tongue and palate, and an eruption of small, white, grayish spots 
over the tongue. He recovered quickly. 
A child was then sick also, but recovered after fifteen davs’ 
ailment. 
Were these true cases of aphtous contagion? Bertarelli in¬ 
serted in the ear of a calf a little thread humected with the saliva 
of the first man and inoculated some of the saliva also in the 
upper lip of a calf. Five days later a typical aphtse developed on 
the lip, and on the ear came a swelling with a little ulcerated 
sore, similar to the manifestations obtained when the experiment 
is made with the saliva of an aphtous bovine—which, by the way, 
is sometimes resorted to as a means of vaccination. 
K 
For the author, this single experiment shows the. possible 
transmission from bovine to man and vice versa, from inoculated 
man to bovine. 
* * 
Determination of Sexes. —To answer more thoroughly, 
at least as far as I could, to an inquiry of one of mv correspond- 
