RINDERPEST AS OBSERVED IN THE PHILIPPINES. 
297 
subcutaneously, while the sick animals received ioo c.c. the first, 
second and third days, with 50 c.c. on the fourth, or more in in¬ 
dividual cases: 
No. 
Inoculated. 
No. 
Sick. 
Deaths. 
Week ending July 7. 
. 36 
59 
1 7 
Week ending July 14. 
. 37 
36 
23 
Week ending July 21. 
23 
12 
Week ending July 28. 
. 1,328 
20 
15 
Week ending August 4. 
• . 357 
1 7 
12 
Week ending August 11. 
. 357 
13 
5 
Total. 
168 
84 
In this case getting men and facilities into the field con¬ 
sumed most of the time, but the third week the real work began. 
Almost immediately the animals that were exposed, having had 
serum given them, the number of sick began to grow less and 
those that were sick and having had sufficient serum and time for 
same to become active they began to convalesce. 
There are three methods of giving immunity against rinder¬ 
pest, viz., the bile method, defibrinated blood method and the 
serum-simultaneous method. 
1. The Bile Method (Eddington) consists in destroying an 
animal affected with or one that has just died from the disease, 
removing the gall bladder by ligating* the neck of same, then 
separating it from the liver beyond the ligature, submerging the 
whole in a 5% carbolic solution, then emptying the bile in a re¬ 
tainer under aseptic precautions, adding one quart of glycerin to 
each two parts of bile, allowing same to stand for eight days, 
when it is ready for use. The glycerin destroys other agents in 
the bile, but does not injure the immunizing powers, rendering 
the same incapable of communicating the disease. The dose is 
20 to 50 c.c., according to size of animal to be inoculated. Ad¬ 
vantages of this method are: It is easily prepared and does not 
require special skill, renders temporary immunity to the exposed 
until the epizootic subsides and, given in large doses to affected 
animals, lessens the attack and may allow patient to recover. 
Disadvantages are: That it is expensive; owing to the small 
amount of bile secured, it is necessary to sacrifice a number of 
animals, some of which might recover; the immunity thus given 
