ARSENICAL POISONING FROM SMELTER SMOKE. 
303 
opment of the natural ulcers at pasture. However, in the produc¬ 
tion of the artificial ulcer the arsenic was applied for only twenty 
minutes at a time on ten different days, while, in the production 
of the natural ulcers, the application was doubtless for 12 to 15 
hours a day for every day while at pasture after the smoke dust 
had been deposited on the grass. The more constant application 
of the smoke dust, therefore, was sufficient to counterbalance its 
lower content in arsenic. 
5. Have similar lesions been observed in man zvhen breathing 
dust containing arsenic ?■—In the quotations already made from 
Harkins and Swain, it has been shown that one of the persons 
who worked on the smelter stack, in determining the arsenic con¬ 
tent of the smoke, had his nostrils almost closed by the inflamma¬ 
tion which resulted from inhaling the smoke dust, while the irri¬ 
tating effect of the dust from grain in the smoke zone was such 
that it seriously affected both the eyes and nasal passages of the 
threshers. 
Some previous observations of this class of lesions are re¬ 
viewed by G. Brouardel, who says 1(5) 
“ The nasal lesions caused by the direct application of arsenic 
transported by the fingers, or by the contact of arsenical dust, 
are quite frequent. Hillairet, according to Rollet, was the first 
to describe these lesions and to show that they might even per¬ 
forate the nasal septum. 
“ According to Delpeuch, there is, at first, inflammation and 
swelling of the mucous membrane; the projecting parts of the 
external wall of the nasal fossae fill the space which separates 
them from the septum and become adherent. In this way occurs 
occlusion of one or both nasal fossae, the nostrils being trans¬ 
formed into culs-de-sac. It is the arsenical dust accumulated 
in these culs-de-sac which causes the ulcerations, and, according 
to Rollet, these occur with the workmen above all on the external 
wall and on the septum. On the external wall two points are 
especially attacked because they project: the anterior extremity 
of the inferior turbinated bone and the projection formed by the 
external branch of the cartilage of the wing of the nose; this 
