336 
ALLEN A. FOSTER. 
This continues for about twenty-four hours; when the veter¬ 
inarian is called he finds the same conditions, only more aggra¬ 
vated. The temperature is from 103 to 105 degrees, respiration 
hurried; strings of this muco-purulent material dribbling from 
the mouth which seem to be very sticky and adheres to the legs 
as the animal endeavors to wipe it off. Pulse from 120 to 150 
and bounding. On raising the lip we observe a yellowish white 
film or membrane covering the surface, varying from the size of 
a hazel-nut to covering the entire surface. Removing this, we 
see a denuded surface very highly congested, hot and painful to 
the touch. The openings of the ducts leading from the mucus 
glands may be easily seen and by holding the membrane for a 
few seconds the small droplets of the secretion collect at each 
opening. Ordinarily at this stage of the disease the infection is 
confined to the mucous membranes external to the teeth. As the 
case proceeds, the infection extends to the tongue, the pharynx, 
and sometimes to the larynx. When this latter structure is in¬ 
volved there is a slight cough. As the case proceeds further there 
is great emaciation, depressed look from the eyes, pulse becomes 
weaker and often intermittent, respiration slow and irregular, 
temperature subnormal, diarrhea and dysentery associated with 
marked tenesmus, membranes of a pale yellowish cast. This 
stage continues about twenty-four to forty-eight hours, often 
longer, patient becoming weaker and weaker, and finally dying 
in coma. 
On post mortem we find the blood in long-continued cases to 
be very thin and watery, while if the case be very rapid the blood 
usually is dark and clots cjuickly. The kidneys, intestines and 
spleen frequently show petechiae. The general macroscopic 
lesions varv considerably, so to undertake to outline a fixed and 
definite picture would be impossible. 
There is always found the dark areas covering the infected 
regions of the mouth which may be accounted for by the tissue 
changes due to the presence of bacterial toxines at the point of 
infection. 
Microscopic examination of sections made through these 
