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produces injurious effects in these animals?” And it was found 
that this question was, at that time, by no means an easy one to 
answer. In order to present the question fairly, the writer will 
bring together such relevant data as he has been able to collect 
bearing upon this point. 
Frohner (i) gives the following table showing the average 
fatal dose of white arsenic in powder: 
By the Stomach. On Wounds. 
Cattle . 15 to 30 grams 2.0 grams 
Horses . 10 to 15 grams 2.0 grams 
Sheep and goats. 10 to 15 grams 0.2 grams 
Swine ( . 0.5 to 1 grams 0.2 grams 
Dogs . 0.1 (to 0.2 grams 0.2 grams 
Kaufman (2) expresses the opinion that it requires 45 grams 
(1.5 ounces) in powder to kill a horse, while 3 to 4 grams (46 to 
62 grains) in solution is sufficient. O11 the other hand, “Per- 
civall mentions that two glandered horses getting 5 grains daily 
in a bolus were attacked, one on the 8th, the other on the 9th day, 
with shivering, loss of appetite, nausea, purging and other symp¬ 
toms of abdominal irritation, imperceptibility of the pulse and 
prostration of strength” (3). 
Porcher (4) says that certain veterinarians have reported 
fatal accidents with the horse following doses of 4 to 5 grams, 
given by the mouth with the object of combating the larvae of 
the Oestrus. The same author refers to a sheep which was not 
incommoded by 32 grams of arsenious acid, also to a report by 
Durrechou of the death of a cow which had only received 5 
grams daily for two days, or 10 grams in all. Detroye, with a 
daily dose of only 1 gram, reported a fistula of the second stom¬ 
ach with a cow. 
Harkins and Swain (5) cite an experiment of Spallanzani 
and Zappa, who fed moderate quantities of arsenic continuously 
to a Durham cow for 46 days, when death resulted. From 0.5 
to 3.0 grams (7.7 to 46.3 grains) of arsenious oxide were ad¬ 
ministered daily, the dose being gradually increased to the maxi- 
r _ _ 
mum, when the animal died. Spallanzani concludes from this 
