4S2 
D. J. MANGAN. 
nostril there was not so many. Along the abdomen were several 
oedematous patches about the size of a man’s fist. The symptoms 
were undoubtedly those of purpura hemorrhagica in the initial 
stage. The animal was injected subcutaneously with 2.5 c.c. of 
the filtrate of the discharge from case No. 10. The next day the 
condition of the animal was wonderful, temperature normal, 
petechia and oedematous swellings completely disappeared. Ani¬ 
mal drank a pail of water and ate one quart of oats. A second 
dose was given four days later and the animal made a rapid 
recovery. 
Case No. 12.—Dark gray gelding, having a fistula of the 
withers of four weeks’ standing. The parts were washed with 
plain tap water and the next morning two tablespoonfuls of pus 
was collected and enough water added to make 12 oz. of the 
mixture. One ounce was given in the mouth every hour, until 
four doses were taken. By mistake the same number of doses 
were administered the next day but without any harm being done. 
The day following the first treatment, the discharge had changed 
to a decided bloody serous exudation and about two drams was 
all that could be expressed from the fistulas tract; the second day 
only a few bubbles of the discharge could be forced out, in com¬ 
parison to the two ounces on the morning on which the treatment 
was commenced. The animal made complete recovery in three 
weeks. No miscroscopical examination was made of this dis¬ 
charge. Four treatments were all that was necessary in this case. 
Concluding Remarks .—Strong antiseptic and astringent solu¬ 
tions are contraindicated, as a rule, when the autogenous antigen 
is being used, because such agents retard the outflow of lymph and 
blood which follows their use. Lymphogogues may be used in 
the place of such solutions. Sod. chloride four per cent, and sod. 
citrate one per cent, in boiled water is a good lymphogogue. 
Generally speaking the more severe the systemic infection the 
smaller should be the dose of antigen employed. Where very 
small doses are given, they may be given more often; in some 
cases daily minute doses being employed. When large doses are 
given the intervals between them should be lengthened. Finally 
