But when we find the toxic substances of many diseases act 
in a curative manner when placed in certain tissues we are 
tempted to formulate rules for their action and classify them ac¬ 
cordingly. It is profitable as a working basis to start in endeavor¬ 
ing to discover how many act in a similar manner and wherein 
their actions differ. 
Rule I. In extra-alimentary and extra-pulmonary diseases if 
the toxic product of the disease is placed in the mouth it null tend 
to develop specific antibodies. The live pathological micro-organ¬ 
isms may be employed in many diseases. 
Rule II. In intra-alimentary and intra-pulnionary diseases if 
the toxic product of the disease be placed in healthy tissues out¬ 
side of these systems , it will tend to develop specific antibodies. 
Upon this common ground all schools of medicine can meet. It 
must be remembered that it is healthy tissues anywhere that de¬ 
velop specific antibodies; it appears, therefore, evident in intra- 
alimentary and intra-pulmonary diseases that the toxic substances 
developed during the course of the disease are already pouring 
into the alimentary canal in massive doses, and if considerable 
quantities of the crude vaccine and the other toxic substances of 
tissue change in addition were placed in the canal, it would be 
not only unbeneficial but harmful. 
First, before we can auto-inoculate, we must obtain the toxic 
substances of the disease; this should be done by every known 
method. All the excretions and secretions of the body should be 
investigated with this object in view. For nature tends to throw 
off or get rid of the toxic substances out of the body. Failing in 
this, nature often auto-inoculates or allows them to escape into 
healthy tissues and cures the disease. Each disease should be 
studied by itself to discover, if possible, which route they take in 
their elimination, for the purpose of obtaining them for re-auto- 
inoculating or auto-therapeutic purposes. It is desirable to re- 
auto-inoculate in many diseases, just how many, clinical experi¬ 
ence and careful laboratory investigations alone will tell. The 
range of application of this principle is very wide and includes 
the vast majority of infectious diseases. 
