J. E. AGHION. 
59() 
horses, mules, nor clogs and though these animals were seen in 
direct contact with cattle affected with foot and mouth disease. 
In order to decide and make sure of this point an experiment 
was carried out in the following manner: 
Two horses, two mules, three native dogs and four head of 
cattle were subjected to a direct inoculation of the virus; the 
buccal mucous membrane and gums were scarified wih a bistoury, 
and a bit of cotton saturated with the saliva and liquid serous of 
pustules of the infected cattle was rubbed vigorously to the parts; 
these animals were kept separately in an isolated pasture and 
daily inspected. None responded to the test, except the (four) 
cattle, which gave a positive reaction, one in forty-eight hours 
and the other three in five clays, from the day the inoculation was 
applied. One of the dogs showed a slight uneasiness the second 
day from the inoculation (was dull and refused food), but got 
well soon afterwards. Now from the result of the above experi¬ 
ment, besides the observation of many others, one may feel confi¬ 
dent in concluding that horses, mules and dogs are not susceptible 
to foot and mouth disease (at least in this country). 
The period of incubation varies from thirty-six hours to four 
days and even more. Animals do not become immune after once 
having the disease. The leading symptoms are: The rise in the 
temperature, dryness of the muzzle, and an eruption appearing in¬ 
side the lips, on the roof of the mouth and tongue. The eruption 
soon breaks, giving rise to ulcers and blisters. While this process 
is going on the mouth becomes sore and the animal shows diffi¬ 
culty in taking food, and mastication may then cease. Small 
blisters also make their appearance in the interdigital space and 
coronets of the feet, causing great pain and severe lameness; in 
bad cases separation of the hoof takes place; this is specially true 
in wet and cold weather. Animals in this condition take a long 
time to recover. In dry weather, the ulcers on the feet rarely 
occur. 
The Treatment .—Ordinary cases of foot and mouth disease 
require very little medical treatment; it is a disease that runs a 
definite course and generally terminates favorably. Nursing is 
