EDITORIAL. 
G40 
the temperature and the appearance of the pirosmoses in the 
'blood. It lasts between two and four days. The temperature 
sometimes goes as high as 41 ° C. This and the presence of the 
parasites, with an acceleration of the pulse, even to 140 per 
minute, rapid jerky respiration, loss of flesh, anaemic mucous 
membranes, constitute the manifestations of this second stage 
which is characterized as belonging to piroplasmosis, only by the 
presence of the parasites. 
The third stage, which is that of the acme of the disease, 
lasts from two* to four days. In the animals experimented upon, 
the temperature dropped to normal or even becomes sub-normal. 
The respiration is accelerated, cardiac palpitations are very 
strong, the animal is very weak, unable to stand up, the coat is 
rough, the tongue dry and saburral. The urine is scarce, dark 
and muddy. There is rhinorrhea and abundant foetid diarrhoea. 
The conjunctiva is congested and icteric. There is sometimes 
abundant flow of tears at the eyes. The fecal matters are liquid, 
yellow and very fetid. The blood contains piroplasms in about 
the same quantity as in the second stage. 
The duration of the fourth stage varies and depends on the 
form of the disease. It is characterized by the following symp¬ 
toms: Dropping of the temperature (36-34° C.), weak pulse, 50- 
40, deep laborious breathing. Cardiac beatings weak. Great 
weakness of the animal. Eyes dull, dirty with purulent crusts 
at the angles, mucous membranes are more or less icteric in color. 
Greenish discharge escapes from the nose. Thick bloody mucus 
from the mouth. Feces are liquid, fetid and reddish. Urine, 
which gradually diminishes until anuria is present, changes col¬ 
oration from yellow to that of dark brown beer. Feces and nasal 
discharge become bloody and finally death takes place, after an 
illness of from five to eight days. 
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* * 
The picture just described, of the dogs used in experiments, is 
the form of the natural disease; it is the most characteristic and 
is called acute because of the severity of the symptoms, of the 
